PDF Diploma in Clinical Medicine and Surgery

Diabetic Ketoacidosis Notes: Definitions, Ketogenesis, Electrolyte Losses and Cerebral Oedema

Two dense pages defining diabetic ketoacidosis clinically and biochemically with the modified Alberti thresholds for serum ketones, bicarbonate and pH. They follow the ketogenesis pathway from lipolysis and free fatty acids through to beta-hydroxybutyrate and acetone, the Kussmaul respirations and fruity breath odour, the osmotic diuresis with its sodium, potassium and chloride deficits, and cerebral oedema as the most common cause of DKA mortality in young children and adolescents.

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