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Gastro-Oesophageal Reflux Disease: Pathophysiology, Symptoms, Complications and Treatment

Defines gastro-oesophageal reflux disease as prolonged reflux of hydrochloric acid and pepsin into the oesophagus, oral cavity and respiratory system, a chronic relapsing condition that leads to oesophagitis. Covers the lower oesophageal sphincter barrier and its risk factors, heartburn and the respiratory symptoms, the complications up to Barrett's oesophagus and adenocarcinoma, the endoscopic and pH-metric diagnosis, lifestyle measures, acid-suppressing drugs and surgery, and oesophageal cancer.

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