Study: Bioinformatics MCQ Practice

help Question 1

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Which of the following is untrue regarding the transmembrane proteins?

A The membrane proteins are also of tremendous biomedical importance

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B They are not drug targets or receptors

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C They are responsible for performing a wide variety of important functions in a cell, such as signal transduction, cross-membrane transport, and energy conversion

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D Constitute up to 30% of all cellular proteins

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help Question 2

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Which of the following is wrong about National Biomedical Research Foundation/Protein Information Resource Sequence Format?

A This is different than PIR format

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B The first line includes an initial “>” character followed by a two-letter code such as P for complete sequence or F for the fragment, followed by a 1 or 2 to indicate type of sequence, then a semicolon, then a four- to six-character unique name for the entry

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C The NBRF format is similar to the FASTA sequence format but with significant differences

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D Sequences retrieved from the PIR database are not in this compact format, but in an expanded format with much more information about the sequence

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help Question 3

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Which of the following is incorrect about ENTREZ?

A It provides a series of forms that can be filled out to retrieve a Medline reference related to the molecular biology sequence databases

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B It provides a series of forms that can be filled out to retrieve a DNA or protein sequence

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C It is a resource prepared only by the staff of the National Center for Biotechnology Information

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D One straightforward way to access the sequence databases is through ENTREZ

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help Question 4

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Which of the following does not describe local alignment algorithm?

A In traceback step, beginning is with the highest score, it ends when 0 is encountered

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B First row and first column are set to 0 in initialization step

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C Score can be negative

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D Negative score is set to 0

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help Question 5

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Which of the following is an abbreviation of MEME?

A Multiple Expectation Maximization for Motif Extraction

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B Mega Expectation Maximization for Motif Elicitation

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C Micro Expectation Maximization for Motif Extraction

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D Multiple Expectation Maximization for Motif Elicitation

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help Question 6

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Which of the following is not a software for dot plot analysis?

A DOTMATCHER

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B LALIGN

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C DOTLET

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D SIMMI

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help Question 7

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Which of the following is not a site on internet for alignment of sequence pairs?

A BLASTN

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B BCM Search Launcher

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C BLASTX

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D SIM

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help Question 8

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Which of the following is true regarding the assumptions in the method of constructing the Dayhoff scoring matrix?

A sites do not vary in their degree of mutability

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B it is assumed that each amino acid position is equally mutable

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C it is assumed that each amino acid position is not equally mutable

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D it is assumed that each amino acid position is not mutable at all

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help Question 9

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Which of the following feature of Bayesian methods is the disadvantage?

A A specific mutational model is required

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B Computationally Bayesian methods are better

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C A length and distance that gives the highest overall probability may be determined

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D They are used to calculate evolutionary distance

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help Question 10

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Which of the following is incorrect regarding sequence homology?

A It is an important concept in sequence analysis

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B When two sequences are descended from a common evolutionary origin, they are said to share homology

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C Two sequences can homologous relationship even if have do not have common origin

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D When two sequences are descended from a common evolutionary origin, they are said to have a homologous relationship

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help Question 11

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What is used to generate parameters for the extreme distribution?

A The pool of alignment scores from the unshuffled sequences

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B The pool of alignment scores from the shuffled sequences

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C The basic optimal score computed at the beginning of the test

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D A single score of a shuffled sequence

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help Question 12

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Which of the following scores are not considered while calculating the SP scores?

A Number of gap penalties

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B All possible pair wise matches

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C All possible mismatches

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D All possible gap costs

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help Question 13

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Which of the following is untrue about the iterative approach?

A Because the order of the sequences used for alignment is different in each iteration

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B This method is not based on heuristic methods

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C The iterative approach is based on the idea that an optimal solution can be found by repeatedly modifying existing suboptimal solutions

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D This method is also heuristic in nature and does not have guarantees for finding the optimal alignment

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help Question 14

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Which of the following is not the objective to perform sequence comparison?

A To find the common motifs present in both sequences

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B To study the physical properties of molecules

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C To study evolutionary relationships

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D To observe patterns of conservation

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help Question 15

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The initial alignments used to produce the guide tree may be obtained by various methods. Which of the following is not one of them?

A pattern-finding approach similar

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B FASTA

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C Faster, full dynamic programming method

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D Fast k-tuple

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help Question 16

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In Genetic Algorithm, in the mutation process _______

A sequence is not changed

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B sequence is changed

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C gaps are not rearranged

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D gaps are not inserted

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help Question 17

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Which of the following is not among the methods for finding localized sequence similarity?

A Extraction of Blocks from a Global or Local MSA

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B Pattern blocking

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C Block Analysis

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D Profile Analysis

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help Question 18

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For the 10-residue DNA sequence example, there are _______ possible starting sites for a 20-residue-long site.

A 70

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B 51

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C 81

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D 40

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help Question 19

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Which of the following is not one of the requirements for implementing algorithms for sequence database searching?

A Speed

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B Size of the dataset

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C Sensitivity

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D Specificity

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help Question 20

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Which of the following is not a variant of BLAST?

A BLASTX

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B TBLASTNX

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C BLASTP

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D BLASTN

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help Question 21

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Which of the following is not correct about FASTA?

A It was in fact the first database similarity search tool developed, preceding the development of BLAST

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B FASTA uses a 'hashing' strategy to find matches for a short stretch of identical residues with a length of k

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C The string of residues is known as blocks

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D Its stands for FAST ALL

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help Question 22

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Which of the following is not a benefit of BLAST?

A Speed

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B Statistical rigor

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C Handling of gaps

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D More sensitive

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help Question 23

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Which of the following is not correct about the Coils and Loops?

A They are irregular structures

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B If the connecting regions are completely irregular, they belong to random coils

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C They are regular structures

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D The loops are often characterized by sharp turns or hairpin-like structures

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help Question 24

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Which of the following is an incorrect statement?

A Molscript is not capable of generating ball-and-stick styles

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B In particular, secondary structure elements can be drawn with solid spirals and arrows representing α-helices and β-strands, respectively

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C Molscript is capable of generating space-filling

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D Molscript is a UNIX program capable of generating wire-frame

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help Question 25

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Which of the following is untrue about SCOP?

A It is constructed almost entirely based on manual examination of protein structures

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B The SCOP families consist of proteins having low sequence identity (>30%)

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C It is a database for comparing and classifying protein structures

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D The proteins are grouped into hierarchies of classes, folds, superfamilies, and families

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help Question 26

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Which of the following is untrue regarding Prediction with Neural Networks?

A A neural network is trained by a single sequence

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B When the sufficiently trained network processes an unknown sequence, it applies the rules learned in training to recognize particular structural patterns

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C When multiple sequence alignments and neural networks are combined, the result is further improved accuracy

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D A neural network is trained by a sequence profile derived from the multiple sequence alignment

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help Question 27

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Which of the following is true regarding Coiled coil?

A They have an integral repeat of seven residues

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B They have an integral repeat of thirty residues

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C The sequence periodicity doesn't contribute in designing algorithms to predict the structural domain

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D They have an integral repeat of twenty residues

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help Question 28

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Which of the following is untrue regarding Chou–Fasman and GOR methods?

A They suffer from the fact that the prediction rules are somewhat arbitrary

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B They are based on single sequence statistics with clear relation to known protein-folding theories

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C They are developed in the 1970s

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D Both are the first-generation methods

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help Question 29

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Which of the following is untrue about homology modeling?

A It doesn't involve the evolutionary distances anywhere

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B The principle behind it is that if two proteins share a high enough sequence similarity, they are likely to have very similar three-dimensional structures

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C Homology modeling predicts protein structures based on sequence homology with known structures

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D It is also known as comparative modeling

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help Question 30

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In the pairwise energy based method, a protein sequence is searched for in a structural fold database to find the best matching structural fold using ______ criteria.

A energy-based

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B residue-based

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C structure-based

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D sequence-based

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quiz Bioinformatics MCQ Practice

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